The 'structural advantage' Warren Buffet mentions is due to the nature of compounded returns and the ability to enter and exit trades swiftly. See... a large hedge fund managing $Billions of dollars cannot enter and exit trades quickly, so they are forced to hold their positions over the long term, hoping their research and proceeding investment work out and they can realize a competitive annual return -- Generally, a 30% annual return is the best a large fund can hope for -- With a small individual account, you can exit and enter trades quickly, capturing smaller returns rapidly, and compounding that strategy over and over.
As you see to the left, starting with only $2500, and hitting 15% gains, will result in breaking $1,000,000 after only 43 trades. Now, this is only to illustrate the power of compounded returns. Of course there will be trades that go against you. But as long as we're cutting losses quickly, and letting our winners run, this type of compounding gains is within reach.